Knee osteoarthritis (OA) is one of the most common joint conditions worldwide. It occurs when the protective cartilage that cushions the ends of the bones gradually wears down over time.

As cartilage deteriorates, bones begin to rub against each other more directly, leading to pain, stiffness, swelling, and reduced mobility.

While osteoarthritis cannot currently be reversed, certain nutrients may help support joint health, reduce inflammation, and improve comfort in people living with knee OA.

Understanding Cartilage

Cartilage is a flexible connective tissue that covers the ends of bones inside joints.

Its main functions include:

• Reducing friction during movement
• Absorbing shock
• Protecting bones from wear and tear
• Supporting smooth joint motion

Unfortunately, cartilage has a very limited ability to repair itself once damaged.

Because of this, preserving existing cartilage becomes extremely important for long-term joint health.

Three Major Factors Behind Osteoarthritis Progression

1. Collagen Loss

Type II collagen forms the structural framework of cartilage.

As we age, collagen production naturally declines, making cartilage weaker and less resilient.

2. Cartilage-Breaking Enzymes

Certain enzymes called matrix metalloproteinases (MMPs) can accelerate cartilage breakdown when they become overly active.

3. Reduced Joint Lubrication

Hyaluronic acid helps maintain synovial fluid, which lubricates joints and reduces friction.

Lower levels may contribute to stiffness and discomfort.

Top 6 Nutrients for Knee Osteoarthritis

6. Undenatured Type II Collagen (UC-II)

UC-II is a specialized form of type II collagen derived from chicken sternum cartilage.

Unlike regular collagen supplements, UC-II appears to work through immune system pathways that may help support cartilage health.

Research has shown improvements in:

• Joint comfort
• Mobility
• Physical function

Typical dose used in studies:

40 mg daily

5. Boswellia Serrata

Boswellia is a traditional herbal extract widely used for inflammatory conditions.

Its active compounds may help reduce inflammatory activity and support joint comfort.

Potential benefits include:

• Reduced stiffness
• Improved mobility
• Better physical function

The remaining four nutrients, food sources, and supplementation tips continue on the next page.